YclJ

• Description: two-component response regulator, active under anaerobic conditions
  
  

Gene name	yclJ
Synonyms
Essential	no
Product	two-component response regulator
Function	unknown
MW, pI	26 kDa, 4.58
Gene length, protein length	681 bp, 227 aa
Immediate neighbours	yclI, yclK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU03750

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: OmpR family of two-component response regulators

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by YclK on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions: YclK-YclJ (putative)

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P94413

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yclJ-yclK PubMed

• Sigma factor:

• Regulation:
  • expressed under anaerobic conditions (ResD) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Elisabeth Härtig, Hao Geng, Anja Hartmann, Angela Hubacek, Richard Münch, Rick W Ye, Dieter Jahn, Michiko M Nakano
Bacillus subtilis ResD induces expression of the potential regulatory genes yclJK upon oxygen limitation.
J Bacteriol: 2004, 186(19);6477-84
[PubMed:15375128] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)