Difference between revisions of "TrpE"
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* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' subject to feedback | + | * '''Effectors of protein activity:''' subject to feedback inhibtion by tryptophan {{PubMed|4956345}} |
* '''Interactions:''' [[PabA]]-[[TrpE]] | * '''Interactions:''' [[PabA]]-[[TrpE]] | ||
| Line 100: | Line 100: | ||
** [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination {{PubMed|8419914}} | ** [[MtrB| TRAP]]: binding to the mRNA in the presence of tryptophan, this results in transcription termination {{PubMed|8419914}} | ||
| − | * '''Additional information:''' subject to feedback | + | * '''Additional information:''' |
| + | ** subject to feedback inhibtion by tryptophan {{PubMed|4956345}} | ||
=Biological materials = | =Biological materials = | ||
| Line 122: | Line 123: | ||
=References= | =References= | ||
| − | <pubmed> 19385727, 19033375, 17881743, 7515880,2422155,3133360,16285852,7678334,7592410, 14976255, 3924737, 6436812,2422155,8419914, 1551827, 16285852 10714985 11566991 12963367 14712717 | + | <pubmed> 19385727, 19033375, 17881743, 7515880,2422155,3133360,16285852,7678334,7592410, 14976255, 3924737, 6436812,2422155,8419914, 1551827, 16285852 10714985 11566991 12963367 14712717 4956345 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 07:09, 15 January 2010
- Description: anthranilate synthase (subunit I)
| Gene name | trpE |
| Synonyms | |
| Essential | no |
| Product | anthranilate synthase (subunit I) |
| Function | biosynthesis of tryptophan |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp | |
| MW, pI | 57 kDa, 5.246 |
| Gene length, protein length | 1545 bp, 515 aa |
| Immediate neighbours | trpD, aroH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU22680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: subject to feedback inhibtion by tryptophan PubMed
- Localization:
Database entries
- Structure:
- UniProt: P03963
- KEGG entry: [3]
- E.C. number: 4.1.3.27
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
- subject to feedback inhibtion by tryptophan PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
