Difference between revisions of "HemC"

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(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
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* '''Operon:''' ''[[hemA]]-[[hemX]]-[[hemC]]-[[hemD]]-[[hemB]]-[[hemL]]'' {{PubMed|1672867}}
  
* '''Operon:'''
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* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1672867}}
 
 
* '''[[Sigma factor]]:'''  
 
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** repressed in the absence of hydrogen peroxide ([[PerR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11532148 PubMed]
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** induced by hydrogen peroxide ([[PerR]]) {{PubMed|11532148}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
** [[PerR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/11532148 PubMed]
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** [[PerR]]: transcription repression {{PubMed|11532148}}
  
* '''Additional information:'''  
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* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =

Revision as of 19:58, 13 December 2009

  • Description: hydroxymethylbilane synthase

Gene name hemC
Synonyms
Essential no
Product hydroxymethylbilane synthase
Function heme biosynthesis
MW, pI 34 kDa, 5.088
Gene length, protein length 942 bp, 314 aa
Immediate neighbours hemD, hemX
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HemC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU28150

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 (according to Swiss-Prot)
  • Protein family: HMBS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References