Difference between revisions of "CcpN"
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** ATP enhances CcpN-dependent repression, ADP counteracts the repressing activity of CcpN [http://www.ncbi.nlm.nih.gov/sites/entrez/18511073 PubMed] | ** ATP enhances CcpN-dependent repression, ADP counteracts the repressing activity of CcpN [http://www.ncbi.nlm.nih.gov/sites/entrez/18511073 PubMed] | ||
| − | * '''Interactions:''' | + | * '''Interactions:''' [[CcpN]]-[[RpoA]] {{PubMed|19726675}} |
* '''Localization:''' | * '''Localization:''' | ||
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=References= | =References= | ||
| − | <pubmed>15720552 16164558 17011578 18511073 18586936, </pubmed> | + | <pubmed>15720552 16164558 17011578 18511073 18586936, 19726675 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:24, 4 September 2009
- Description: transcriptional repressor of gluconeogenetic genes and of sr1. repression in the presence of glucose
| Gene name | ccpN |
| Synonyms | yqzB |
| Essential | no |
| Product | transcriptional regulator |
| Function | repressor of genes involved in gluconeogenesis (gapB, pckA) and of sr1 |
| Metabolic function and regulation of this protein in SubtiPathways: Ammonium/ glutamate, Cys, Met & Sulfate assimilation, Central C-metabolism | |
| MW, pI | 23.4 kDa, 7.22 |
| Gene length, protein length | 636 bp, 212 amino acids |
| Immediate neighbours | yqfL, glyS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU25250
Phenotypes of a mutant
Impaired growth on glucose due to re-routing of carbon from glycolysis to the pentose phosphate pathway PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription repression of the gapB, pckA, and sr1 genes in the presence of glucose PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: O34994
- KEGG entry: [3]
Additional information
Expression and regulation
- Regulation: constitutively expressed PubMed
- Additional information:
Biological materials
- Mutant: DB104 ccpN::cat, available in Sabine Brantl lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- Antibody: available in Sabine Brantl lab
Labs working on this gene/protein
Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France
Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany homepage
Uwe Sauer, ETH Zürich, Switzerland homepage
Your additional remarks
References
