Difference between revisions of "HemB"

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* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P30950 P30950]
 
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P30950 P30950]
  
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU28130]
+
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28130]
  
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/4.2.1.24 4.2.1.24]
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/4.2.1.24 4.2.1.24]

Revision as of 02:37, 25 June 2009

  • Description: porphobilinogen synthase

Gene name hemB
Synonyms
Essential no
Product porphobilinogen synthase
Function heme biosynthesis
MW, pI 36 kDa, 4.98
Gene length, protein length 972 bp, 324 aa
Immediate neighbours hemL, hemD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HemB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU28130

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2 5-aminolevulinate = porphobilinogen + 2 H2O (according to Swiss-Prot)
  • Protein family: ALADH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed in the absence of hydrogen peroxide (PerR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References