GntP

• Description: gluconate permease
  
  

Gene name	gntP
Synonyms
Essential	no
Product	gluconate permease
Function	gluconate uptake
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	46 kDa, 8.098
Gene length, protein length	1344 bp, 448 aa
Immediate neighbours	gntK, gntZ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40070

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: gntP permease family (according to Swiss-Prot)

• Paralogous protein(s): YojA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: P12012

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: gntR-gntK-gntP-gntZ PubMed1 PubMed2

• Sigma factor: SigA PubMed

• Regulation:
  • induced by gluconate (GntR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • GntR: transcription repression PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Fujita Y, Fujita T, Miwa Y, Nihashi J, Aratani Y. (1986) Organization and transcription of the gluconate operon, gnt, of Bacillus subtilis. J Biol Chem. Oct 15;261(29): 13744-53. PubMed
2. Reizer A., Deutscher J., Saier M.H. Jr., Reizer J. (1991) Analysis of the gluconate (gnt) operon of Bacillus subtilis. Mol. Microbiol. 5: 1081-1089. PubMed
3. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed