TrpE

• Description: anthranilate synthase
  
  

Gene name	trpE
Synonyms
Essential	no
Product	anthranilate synthase
Function	biosynthesis of tryptophan
MW, pI	57 kDa, 5.246
Gene length, protein length	1545 bp, 515 aa
Immediate neighbours	trpD, aroH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry: P03963

• KEGG entry: BSU22680

• E.C. number: 4.1.3.27

Expression and regulation

• Operon: trpE-trpD-trpC-trpF-trpB-trpA PubMed

• Sigma factor: SigA PubMed

• Regulation: induction by tryptophan ( TRAP)

• Regulatory mechanism: TRAP: binding to the mRNA in the presence of tryptophan, this results in transcription termination

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed