YwcA

• Description: similar to Na+-dependent symport
  
  

Gene name	ywcA
Synonyms	ipa-31r
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: ywcA
Metabolic function and regulation of this protein in SubtiPathways: YwcA
MW, pI	54 kDa, 7.201
Gene length, protein length	1548 bp, 516 aa
Immediate neighbours	ywcB, ywbO
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, membrane proteins, sporulation proteins

This gene is a member of the following regulons

SigE regulon

The gene

Basic information

• Locus tag: BSU38240

Phenotypes of a mutant

• • ywcBA mutant has slightly reduced acetic acid transport PubMed
  • ywcBA mutant shows earlier pellicle biofilm formation PubMed

Database entries

• BsubCyc: BSU38240

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • the protein is involved in acetate transport PubMed
  • the protein is not involved in proline transport PubMed

• Protein family: solute:sodium symporter family (SSS family)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU38240

• Structure:

• UniProt: P39599

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:
  • slrA-ywcB-ywcA
  • ywcB-ywcA

• Expression browser: ywcA PubMed

• Sigma factor:
  • ywcB: SigE PubMed

• Regulation: expressed during sporulation (SigE) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • available in Erhard Bremer's lab PubMed

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Adrienne Zaprasis, Tamara Hoffmann, Lorena Stannek, Katrin Gunka, Fabian M Commichau, Erhard Bremer
The γ-aminobutyrate permease GabP serves as the third proline transporter of Bacillus subtilis.
J Bacteriol: 2014, 196(3);515-26
[PubMed:24142252] [WorldCat.org] [DOI] (I p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)