FhuC

• Description: hydroxamate siderophore ABC transporter (ATP-binding protein) (ferrichrome und ferrioxamine)
  
  

Gene name	fhuC
Synonyms
Essential	no
Product	hydroxamate siderophore ABC transporter (ATP-binding protein) (ferrichrome und ferrioxamine)
Function	siderophore uptake
Gene expression levels in SubtiExpress: fhuC
Interactions involving this protein in SubtInteract: FhuC
Metabolic function and regulation of this protein in SubtiPathways: FhuC
MW, pI	29 kDa, 6.499
Gene length, protein length	807 bp, 269 aa
Immediate neighbours	yvrP, fhuG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, acquisition of iron, iron metabolism, membrane proteins

This gene is a member of the following regulons

Fur regulon

The gene

Basic information

• Locus tag: BSU33290

Database entries

• BsubCyc: BSU33290

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + H₂O + iron chelate(Out) = ADP + phosphate + iron chelate(In) (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • FhuC-(FhuB-FhuG)-(FhuD-YxeB) PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU33290

• Structure:

• UniProt: P49938

• KEGG entry: [2]

• E.C. number: 3.6.3.34

Expression and regulation

• Operon:

• Expression browser: fhuC PubMed

• Sigma factor:

• Regulation:
  • induced upon iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 86 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Juliane Ollinger, Kyung-Bok Song, Haike Antelmann, Michael Hecker, John D Helmann
Role of the Fur regulon in iron transport in Bacillus subtilis.
J Bacteriol: 2006, 188(10);3664-73
[PubMed:16672620] [WorldCat.org] [DOI] (P p)

Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)