Difference between revisions of "YvrHb"

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* '''Additional information:'''
 
* '''Additional information:'''
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** number of protein molecules per cell (minimal medium with glucose and ammonium): 267 {{PubMed|24696501}}
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** number of protein molecules per cell (complex medium with amino acids, without glucose): 459 {{PubMed|24696501}}
  
 
=Biological materials =
 
=Biological materials =

Revision as of 09:32, 17 April 2014

Gene name yvrHb
Synonyms yvrH
Essential no
Product two-component response regulator
Function regulation cell surface maintenance
Gene expression levels in SubtiExpress: yvrHb
Interactions involving this protein in SubtInteract: YvrHB
MW, pI 27 kDa, 5.235
Gene length, protein length 711 bp, 237 aa
Immediate neighbours yvrG, yvrHa
Gene sequence (+200bp) Protein sequence
Genetic context
YvrHa yvrHb context.GIF
Expression at a glance   PubMed
YvrHb expression.png
























Categories containing this gene/protein

transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

The YvrHb regulon

The gene

Basic information

  • Locus tag: BSU33221

Phenotypes of a mutant

unusual autolysis and higher susceptibility to cell envelope antibiotics (bacitracin, aztreonam, cefepime, fosfomycin) PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: no entry

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activator PubMed
  • Protein family: OmpR family
  • Paralogous protein(s):

The YvrHb regulon

subject to positive control: dltA-dltB-dltC-dltD-dltE, sigX-rsiX, sunA, sunT-bdbA-yolJ-bdbB, wapA-yxxG, wprA, yvrI-yvrHa PubMed

subject to negative control: lytA-lytB-lytC PubMed

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation (Asp) by YvrG PubMed
  • Cofactor(s):
  • Effectors of protein activity: phosphorylation likely affects DNA-binding activity

Database entries

  • Structure:
  • KEGG entry: [1]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 267 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 459 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Letal I Salzberg, John D Helmann
Phenotypic and transcriptomic characterization of Bacillus subtilis mutants with grossly altered membrane composition.
J Bacteriol: 2008, 190(23);7797-807
[PubMed:18820022] [WorldCat.org] [DOI] (I p)

Masakuni Serizawa, Keisuke Kodama, Hiroki Yamamoto, Kazuo Kobayashi, Naotake Ogasawara, Junichi Sekiguchi
Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses.
Biosci Biotechnol Biochem: 2005, 69(11);2155-69
[PubMed:16306698] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)