Tpx

• Description: probable thiol peroxidase
  
  

Gene name	tpx
Synonyms	ytgI
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: tpx
MW, pI	18 kDa, 4.698
Gene length, protein length	501 bp, 167 aa
Immediate neighbours	ytxK, gerW
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

Spx regulon

The gene

Basic information

• Locus tag: BSU29490

Database entries

• BsubCyc: BSU29490

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Tpx subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU29490

• Structure: 2JSZ

• UniProt: P80864

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: tpx PubMed

• Expression browser: tpx PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • Spx: transcription activation PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 9315 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 12273 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jie Lu, Fan Yang, You Li, Bin Xia, Changwen Jin
1H, 13C, and 15N resonance assignments of the reduced and oxidized forms of Bacillus subtilis thiol peroxidase.
Biomol NMR Assign: 2008, 2(2);183-6
[PubMed:19636900] [WorldCat.org] [DOI] (I p)

Shunji Nakano, Michiko M Nakano, Ying Zhang, Montira Leelakriangsak, Peter Zuber
A regulatory protein that interferes with activator-stimulated transcription in bacteria.
Proc Natl Acad Sci U S A: 2003, 100(7);4233-8
[PubMed:12642660] [WorldCat.org] [DOI] (P p)

Alia Lapidus, Nathalie Galleron, Alexei Sorokin, S Dusko Ehrlich
Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.
Microbiology (Reading): 1997, 143 ( Pt 11);3431-3441
[PubMed:9387221] [WorldCat.org] [DOI] (P p)