mprF
168

synthesis of lysylphosphatidylglycerol (L-PG), lysinylation of phosphatidylglycerol provides some resistance against positively charged antimicrobial peptides

Locus

BSU_08425

Molecular weight

96.00 kDa

Isoelectric point

Protein length

856 aaSequenceBlast

Gene length

2571 bpSequenceBlast

Function

lysyl-phosphatidylglycerol lipid biosynthesis

Product

lysyl-phosphatidylglycerol synthase

Essential

Synonyms

mprF, yfiW, yfiX

Outlinks

BsubCyc UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2898 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

916,778 919,348

Phenotypes of a mutant

reduced conjugation of ICEBs1 PubMed

overexpression results in increased conjugation of ICEBs1 PubMed

suppression of the growth defect of a strain lacking all four class A penicillin-binding proteins (ponA pbpD pbpF pbpG) on complex medium PubMed

The protein

Catalyzed reaction/ biological activity

1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA^Lys --> 1,2-diacyl-sn-glycero-3-phospho-1ʼ-(3ʼ-O-L-lysyl)-sn-glycerol + tRNA^Lys (according to UniProt)

Protein family

LPG synthase family (single member, according to UniProt)

Structure

4V36 (PDB) (Lys-tRNA(Lys)-dependent lysyl-phosphatidylglycerol synthase domain from B. licheniformis, 76% identity) PubMed

C0H3X7 (AlphaFold)

Localization

cell membrane at the septum PubMed

Expression and Regulation

Operons

Genes

mprF

Description