Difference between revisions of "MurAB"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU37100&redirect=T BSU37100] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU37100&redirect=T BSU37100] | ||
* '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3SG1 3SG1] (from ''B. anthracis'', 50% identity, 81% similarity) | * '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3SG1 3SG1] (from ''B. anthracis'', 50% identity, 81% similarity) | ||
Revision as of 15:03, 2 April 2014
- Description: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
| Gene name | murAB |
| Synonyms | murZ, lssF, rev-4 |
| Essential | no |
| Product | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
| Function | peptidoglycan precursor biosynthesis |
| Gene expression levels in SubtiExpress: murAB | |
| Metabolic function and regulation of this protein in SubtiPathways: murAB | |
| MW, pI | 45 kDa, 5.831 |
| Gene length, protein length | 1287 bp, 429 aa |
| Immediate neighbours | glpX, ywjH |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of cell wall components
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU37100
Phenotypes of a mutant
Database entries
- BsubCyc: BSU37100
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine (according to Swiss-Prot)
- Protein family: MurA subfamily (according to Swiss-Prot)
- Paralogous protein(s): MurAA
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU37100
- Structure: 3SG1 (from B. anthracis, 50% identity, 81% similarity)
- UniProt: P19670
- KEGG entry: [2]
- E.C. number: 2.5.1.7
Additional information
Expression and regulation
- Regulation: constitutive PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- pGP2595: (IPTG inducible expression, purification in E. coli with N-terminal His-tag, in pWH844), available in Jörg Stülke's lab
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Ankur Gautam, Praveen Rishi, Rupinder Tewari
UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments.
Appl Microbiol Biotechnol: 2011, 92(2);211-25
[PubMed:21822642]
[WorldCat.org]
[DOI]
(I p)
Original publications
