HelD

• Description: DNA 3'-5' helicase IV, stimulates transcription in an ATP-dependent manner by enhancing transcriptional cycling and elongation
  
  

Gene name	helD
Synonyms	yvgS
Essential	no
Product	DNA 3'-5' helicase IV
Function	transcription, DNA repair/ recombination
Gene expression levels in SubtiExpress: helD
MW, pI	89 kDa, 6.083
Gene length, protein length	2322 bp, 774 aa
Immediate neighbours	cysI, yvgT
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, transcription

The gene

Basic information

• Locus tag: BSU33450

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: UvrD subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • HelD interacts with the RNA polymerase core enzyme PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3DMN (C-terminal domain of the protein from Lactobacillus plantarum, 39% identity)

• UniProt: O32215

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: helD PubMed

• Expression browser: helD PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A899 ( helD::erm), available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: