Difference between revisions of "HisD"
| Line 58: | Line 58: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU34910&redirect=T BSU34910] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
| Line 95: | Line 96: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU34910&redirect=T BSU34910] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1KAH 1KAH] (with product and NAD from ''Escherichia coli'', 39% identity, 58% similarity) {{PubMed|11842181}} | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1KAH 1KAH] (with product and NAD from ''Escherichia coli'', 39% identity, 58% similarity) {{PubMed|11842181}} | ||
Revision as of 14:53, 2 April 2014
- Description: histidinol dehydrogenase
| Gene name | hisD |
| Synonyms | |
| Essential | no |
| Product | histidinol dehydrogenase |
| Function | biosynthesis of histidine |
| Gene expression levels in SubtiExpress: hisD | |
| Metabolic function and regulation of this protein in SubtiPathways: hisD | |
| MW, pI | 46 kDa, 4.777 |
| Gene length, protein length | 1281 bp, 427 aa |
| Immediate neighbours | hisB, hisG |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU34910
Phenotypes of a mutant
Database entries
- BsubCyc: BSU34910
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-histidinol + 2 NAD+ = L-histidine + 2 NADH (according to Swiss-Prot)
- Protein family: histidinol dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU34910
- UniProt: O34651
- KEGG entry: [2]
- E.C. number: 1.1.1.23
Additional information
Expression and regulation
- Sigma factor:
- Regulation: repressed by casamino acids PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147]
[WorldCat.org]
[DOI]
(P p)
