Difference between revisions of "ValS"

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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
 
{{SubtiWiki category|[[translation]]}},
 
{{SubtiWiki category|[[translation]]}},
{{SubtiWiki category|[[essential genes]]}}
+
{{SubtiWiki category|[[essential genes]]}},
 +
[[most abundant proteins]]
  
 
= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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* '''Additional information:'''
 
* '''Additional information:'''
 
** [[translation]] is likely to require [[Efp]] due to the presence of several consecutive proline residues {{PubMed|23239624,23239623}}
 
** [[translation]] is likely to require [[Efp]] due to the presence of several consecutive proline residues {{PubMed|23239624,23239623}}
 +
** belongs to the 100 [[most abundant proteins]] {{PubMed|15378759}}
  
 
=Biological materials =
 
=Biological materials =
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<pubmed>19258532,, </pubmed>
 
<pubmed>19258532,, </pubmed>
 
==Original Publications==
 
==Original Publications==
<pubmed>,9098041, </pubmed>
+
<pubmed>,9098041, 15378759</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 16:41, 5 March 2014

  • Description: valyl-tRNA synthetase

Gene name valS
Synonyms
Essential yes PubMed
Product valyl-tRNA synthetase
Function translation
Gene expression levels in SubtiExpress: valS
Metabolic function and regulation of this protein in SubtiPathways:
valS
MW, pI 101 kDa, 4.868
Gene length, protein length 2640 bp, 880 aa
Immediate neighbours folC, yszA
Sequences Protein DNA DNA_with_flanks
Genetic context
ValS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ValS expression.png















Categories containing this gene/protein

translation, essential genes, most abundant proteins

This gene is a member of the following regulons

T-box, Efp-dependent proteins

The gene

Basic information

  • Locus tag: BSU28090

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val) (according to Swiss-Prot)
  • Protein family: ValS type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 1IYW (from Thermus thermophilus, 41% identity, 60% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications