Difference between revisions of "AhrC"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24250&redirect=T BSU24250] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ahrC-recN.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ahrC-recN.html] | ||
| Line 92: | Line 93: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24250&redirect=T BSU24250] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2P5M 2P5M] (C-Terminus), [http://www.rcsb.org/pdb/explore.do?structureId=2P5K 2P5K] (complex with an 18bp DNA operator), [http://www.rcsb.org/pdb/explore.do?structureId=2P5L 2P5L] (N-terminus), [http://www.rcsb.org/pdb/explore.do?structureId=1F9N 1F9N], [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=18637 NCBI] [http://www.ncbi.nlm.nih.gov/sites/entrez/18455186 PubMed],N-Terminus [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=60156 NCBI], C-Terminus [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=60157 NCBI], complex with an 18bp DNA operator [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=62912 NCBI] | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2P5M 2P5M] (C-Terminus), [http://www.rcsb.org/pdb/explore.do?structureId=2P5K 2P5K] (complex with an 18bp DNA operator), [http://www.rcsb.org/pdb/explore.do?structureId=2P5L 2P5L] (N-terminus), [http://www.rcsb.org/pdb/explore.do?structureId=1F9N 1F9N], [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=18637 NCBI] [http://www.ncbi.nlm.nih.gov/sites/entrez/18455186 PubMed],N-Terminus [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=60156 NCBI], C-Terminus [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=60157 NCBI], complex with an 18bp DNA operator [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=62912 NCBI] | ||
Revision as of 14:10, 2 April 2014
- Description: AhrC represses the genes for arginine biosynthesis and activates the genes for arginine catabolism.
| Gene name | ahrC |
| Synonyms | argR |
| Essential | no |
| Product | transcriptional regulator |
| Function | transcriptional regulator of arginine metabolic genes |
| Gene expression levels in SubtiExpress: ahrC | |
| Metabolic function and regulation of this protein in SubtiPathways: ahrC | |
| MW, pI | 16,7 kDa, 5.52 |
| Gene length, protein length | 447 bp, 149 amino acids |
| Immediate neighbours | recN, yqxC |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, glutamate metabolism, utilization of amino acids, transcription factors and their control
This gene is a member of the following regulons
The AhrC regulon
The gene
Basic information
- Locus tag: BSU24250
Phenotypes of a mutant
Database entries
- BsubCyc: BSU24250
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcriptional activator/ repressor of genes involved in arginine metabolism
- Protein family: argR family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): L-arginine is the co-factor required for transcription repression/ activation
- Effectors of protein activity:
- Localization: Cytoplasm
Database entries
- BsubCyc: BSU24250
- Structure: 2P5M (C-Terminus), 2P5K (complex with an 18bp DNA operator), 2P5L (N-terminus), 1F9N, NCBI PubMed,N-Terminus NCBI, C-Terminus NCBI, complex with an 18bp DNA operator NCBI
- UniProt: P17893
- KEGG entry: [3]
Additional information
Expression and regulation
- Sigma factor:
- Additional information:
Biological materials
- Mutant: GP729 (aphA3), available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- Antibody:
Labs working on this gene/protein
Simon Phillips, Leeds University, UK Homepage
Michel Debarbouille, Pasteur Institute, Paris, France Homepage
Your additional remarks
References
Additional publications: PubMed
