Difference between revisions of "BrxB"
| Line 14: | Line 14: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]] | |style="background:#ABCDEF;" align="center"|'''Function''' || de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]] | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU23990 | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU23990 brxB] |
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=BrxB BrxB] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 4.814 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 4.814 | ||
| Line 68: | Line 70: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| + | ** de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]] {{PubMed|24313874}} | ||
* '''Protein family:''' UPF0403 family (according to Swiss-Prot) | * '''Protein family:''' UPF0403 family (according to Swiss-Prot) | ||
| Line 85: | Line 88: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| + | ** [[BrxB]]-[[MetE]] {{PubMed|24313874}} | ||
| + | ** [[BrxB]]-[[OhrR]] {{PubMed|24313874}} | ||
| − | * '''Localization:''' cell membrane (according to Swiss-Prot) | + | * '''[[Localization]]:''' cell membrane (according to Swiss-Prot) |
=== Database entries === | === Database entries === | ||
| Line 105: | Line 110: | ||
* '''Operon:''' ''brxB'' (according to [http://dbtbs.hgc.jp/COG/prom/yqiW.html DBTBS]) | * '''Operon:''' ''brxB'' (according to [http://dbtbs.hgc.jp/COG/prom/yqiW.html DBTBS]) | ||
| − | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqiW_2493064_2493501_-1 | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqiW_2493064_2493501_-1 brxB] {{PubMed|22383849}} |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
Revision as of 19:17, 13 December 2013
- Description: bacilliredoxin
| Gene name | brxB |
| Synonyms | yqiW |
| Essential | no |
| Product | bacilliredoxin |
| Function | de-bacillithiolation of S-bacillithiolated OhrR and MetE |
| Gene expression levels in SubtiExpress: brxB | |
| Interactions involving this protein in SubtInteract: BrxB | |
| MW, pI | 16 kDa, 4.814 |
| Gene length, protein length | 435 bp, 145 aa |
| Immediate neighbours | artP, bmrU |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
membrane proteins, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU23990
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UPF0403 family (according to Swiss-Prot)
- Paralogous protein(s): BrxA
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P54534
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Operon: brxB (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
YpdA, BrxA, BrxB and YtxJ cooccur in those species predicted to synthesize bacillithiol.
References
Ahmed Gaballa, Bui Khanh Chi, Alexandra A Roberts, Dörte Becher, Chris J Hamilton, Haike Antelmann, John D Helmann
Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE.
Antioxid Redox Signal: 2014, 21(3);357-67
[PubMed:24313874]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541]
[WorldCat.org]
[DOI]
(I p)
