Difference between revisions of "PolC"
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* '''Structure:''' | * '''Structure:''' | ||
| + | ** [http://www.pdb.org/pdb/explore/explore.do?structureId=3f2b 3F2B] (from ''Geobacillus kaustophilus'', 71% identity) {{PubMed|19106298}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/P13267 P13267] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P13267 P13267] | ||
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=References= | =References= | ||
| − | <pubmed>15186423, 20122408,11721055 23563155 23268446,21740522,21958350 24062730 24106089</pubmed> | + | == Reviews == |
| + | <pubmed> 19106294</pubmed> | ||
| + | == Original publications == | ||
| + | <pubmed>15186423, 20122408,11721055 23563155 23268446,21740522,21958350 24062730 24106089 19106298</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:10, 17 November 2013
- Description: DNA polymerase III (alpha subunit), part of the replisome
| Gene name | polC |
| Synonyms | mutI, dnaF, dnaP |
| Essential | yes PubMed |
| Product | DNA polymerase III (alpha subunit) |
| Function | DNA replication |
| Gene expression levels in SubtiExpress: polC | |
| Interactions involving this protein in SubtInteract: PolC | |
| MW, pI | 162 kDa, 5.135 |
| Gene length, protein length | 4311 bp, 1437 aa |
| Immediate neighbours | proS, ylxS |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA replication, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16580
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
- required for bacteriophage SPP1 replication PubMed
- Protein family: PolC subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- forms foci PubMed
- cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P13267
- KEGG entry: [2]
- E.C. number: 2.7.7.7
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Meindert H Lamers, Mike O'Donnell
A consensus view of DNA binding by the C family of replicative DNA polymerases.
Proc Natl Acad Sci U S A: 2008, 105(52);20565-6
[PubMed:19106294]
[WorldCat.org]
[DOI]
(I p)
Original publications
