PreQ1 riboswitch

This riboswitch controls the expression of the queC-queD-queE-queF operon in response to the availability of queuosine. In the absence of queuosine, the riboswitch allows transcriptional antitermination.

Structure of this riboswitch

Zhou Gong, Yunjie Zhao, Changjun Chen, Yong Duan, Yi Xiao
Insights into ligand binding to PreQ1 Riboswitch Aptamer from molecular dynamics simulations.
PLoS One: 2014, 9(3);e92247
[PubMed:24663240] [WorldCat.org] [DOI] (I e)

Krishna C Suddala, Arlie J Rinaldi, Jun Feng, Anthony M Mustoe, Catherine D Eichhorn, Joseph A Liberman, Joseph E Wedekind, Hashim M Al-Hashimi, Charles L Brooks, Nils G Walter
Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure.
Nucleic Acids Res: 2013, 41(22);10462-75
[PubMed:24003028] [WorldCat.org] [DOI] (I p)

Joseph A Liberman, Mohammad Salim, Jolanta Krucinska, Joseph E Wedekind
Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold.
Nat Chem Biol: 2013, 9(6);353-5
[PubMed:23584677] [WorldCat.org] [DOI] (I p)

Zhou Gong, Yunjie Zhao, Changjun Chen, Yi Xiao
Computational study of unfolding and regulation mechanism of preQ1 riboswitches.
PLoS One: 2012, 7(9);e45239
[PubMed:23028870] [WorldCat.org] [DOI] (I p)

Qi Zhang, Mijeong Kang, Robert D Peterson, Juli Feigon
Comparison of solution and crystal structures of preQ1 riboswitch reveals calcium-induced changes in conformation and dynamics.
J Am Chem Soc: 2011, 133(14);5190-3
[PubMed:21410253] [WorldCat.org] [DOI] (I p)

Jun Feng, Nils G Walter, Charles L Brooks
Cooperative and directional folding of the preQ1 riboswitch aptamer domain.
J Am Chem Soc: 2011, 133(12);4196-9
[PubMed:21375305] [WorldCat.org] [DOI] (I p)

Mijeong Kang, Robert Peterson, Juli Feigon
Structural Insights into riboswitch control of the biosynthesis of queuosine, a modified nucleotide found in the anticodon of tRNA.
Mol Cell: 2009, 33(6);784-90
[PubMed:19285444] [WorldCat.org] [DOI] (I p)

Daniel J Klein, Thomas E Edwards, Adrian R Ferré-D'Amaré
Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.
Nat Struct Mol Biol: 2009, 16(3);343-4
[PubMed:19234468] [WorldCat.org] [DOI] (I p)

Adam Roth, Wade C Winkler, Elizabeth E Regulski, Bobby W K Lee, Jinsoo Lim, Inbal Jona, Jeffrey E Barrick, Ankita Ritwik, Jane N Kim, Rüdiger Welz, Dirk Iwata-Reuyl, Ronald R Breaker
A riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain.
Nat Struct Mol Biol: 2007, 14(4);308-17
[PubMed:17384645] [WorldCat.org] [DOI] (P p)

See also:

• RNA switch