Difference between revisions of "YabA"
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| − | * '''Description:''' tethers [[DnaA]] to the polymerase-clamp protein [[DnaN]] <br/><br/> | + | * '''Description:''' inhibitor of [[DnaA]] oligomerization, tethers [[DnaA]] to the polymerase-clamp protein [[DnaN]] <br/><br/> |
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** associates with the ''oriC'' region in a [[DnaA]]-dependent manner, this limits the amount of [[DnaA]] that can bind the ''oriC'' region {{PubMed|21895792}} | ** associates with the ''oriC'' region in a [[DnaA]]-dependent manner, this limits the amount of [[DnaA]] that can bind the ''oriC'' region {{PubMed|21895792}} | ||
** YabA inhibits co-operative DNA binding by [[DnaA]] {{PubMed|21895792}} | ** YabA inhibits co-operative DNA binding by [[DnaA]] {{PubMed|21895792}} | ||
| + | ** inhibits oligomerization and helix formation of [[DnaA]] {{PubMed|23909787}} | ||
* '''Protein family:''' yabA family (according to Swiss-Prot) | * '''Protein family:''' yabA family (according to Swiss-Prot) | ||
Revision as of 16:46, 8 August 2013
| Gene name | yabA |
| Synonyms | |
| Essential | no |
| Product | negative regulator of replication initiation |
| Function | positioning of DnaA |
| Gene expression levels in SubtiExpress: yabA | |
| Interactions involving this protein in SubtInteract: YabA | |
| MW, pI | 13 kDa, 6.065 |
| Gene length, protein length | 357 bp, 119 aa |
| Immediate neighbours | yaaT, yabB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00330
Phenotypes of a mutant
strongly reduced growth rate in minimal medium PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: yabA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: leucine zipper
- Modification:
- Cofactor(s): Zn cluster
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P37542
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Philippe Noirot, Jouy-en-Josas, France Homepage
Alan Grossman, Cambridge, MA, USA Homepage
Your additional remarks
References
Reviews
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337]
[WorldCat.org]
[DOI]
(I p)
Original publications
Graham Scholefield, Heath Murray
YabA and DnaD inhibit helix assembly of the DNA replication initiation protein DnaA.
Mol Microbiol: 2013, 90(1);147-59
[PubMed:23909787]
[WorldCat.org]
[DOI]
(I p)
Houra Merrikh, Alan D Grossman
Control of the replication initiator DnaA by an anti-cooperativity factor.
Mol Microbiol: 2011, 82(2);434-46
[PubMed:21895792]
[WorldCat.org]
[DOI]
(I p)
Alexi I Goranov, Adam M Breier, Houra Merrikh, Alan D Grossman
YabA of Bacillus subtilis controls DnaA-mediated replication initiation but not the transcriptional response to replication stress.
Mol Microbiol: 2009, 74(2);454-66
[PubMed:19737352]
[WorldCat.org]
[DOI]
(I p)
Avigdor Eldar, Vasant K Chary, Panagiotis Xenopoulos, Michelle E Fontes, Oliver C Losón, Jonathan Dworkin, Patrick J Piggot, Michael B Elowitz
Partial penetrance facilitates developmental evolution in bacteria.
Nature: 2009, 460(7254);510-4
[PubMed:19578359]
[WorldCat.org]
[DOI]
(I p)
Clarisse Defeu Soufo, Hervé Joël Defeu Soufo, Marie-Françoise Noirot-Gros, Astrid Steindorf, Philippe Noirot, Peter L Graumann
Cell-cycle-dependent spatial sequestration of the DnaA replication initiator protein in Bacillus subtilis.
Dev Cell: 2008, 15(6);935-41
[PubMed:19081080]
[WorldCat.org]
[DOI]
(I p)
Marie-Françoise Noirot-Gros, M Velten, M Yoshimura, S McGovern, T Morimoto, S D Ehrlich, N Ogasawara, P Polard, Philippe Noirot
Functional dissection of YabA, a negative regulator of DNA replication initiation in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2006, 103(7);2368-73
[PubMed:16461910]
[WorldCat.org]
[DOI]
(P p)
Marie-Françoise Noirot-Gros, Etienne Dervyn, Ling Juan Wu, Peggy Mervelet, Jeffery Errington, S Dusko Ehrlich, Philippe Noirot
An expanded view of bacterial DNA replication.
Proc Natl Acad Sci U S A: 2002, 99(12);8342-7
[PubMed:12060778]
[WorldCat.org]
[DOI]
(P p)
