ECF transporter

Parent categories	1. Cellular processes 1.2. Transporters
Neighbouring categories	1.2.1. ABC transporters 1.2.2. Phosphotransferase systems 1.2.3. ECF transporter 1.2.4. Transporters/ other
Related categories	transport proteins
Overview on the categories (Excel file) All genes and their categories (Excel file)

ECF transporters are required for the uptake of micronutrients such as cofactors (vitamins), metal ions, or amino acids. The transporters are composed of three general components (membrane spanning T protein und two ATP-hydrolyzing A proteins) and substrate-specific S proteins. In B. subtilis, there are four known substrates for ECF transporters, riboflavin, thiamine, biotin, and tryptophan.

The general components of the ECF transporters

• ybxA ATP-binding A1 protein (EcfA1)
• ybaE ATP-binding A2 protein (EcfA2)
• ybaF membrane-spanning T protein (EcfT)

The substrate-specific S components of the ECF transporters

• RibU: uptake of riboflavin
• ThiT: uptake of thiamine
• YhfU: uptake of biotin
• TrpP: uptake of tryptophan
• YuiG: unknown specificity, may also transport biotin

Important reviews and publications

Ke Xu, Minhua Zhang, Qin Zhao, Fang Yu, Hui Guo, Chengyuan Wang, Fangyuan He, Jianping Ding, Peng Zhang
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis.
Nature: 2013, 497(7448);268-71
[PubMed:23584589] [WorldCat.org] [DOI] (I p)

Josy ter Beek, Ria H Duurkens, Guus B Erkens, Dirk Jan Slotboom
Quaternary structure and functional unit of energy coupling factor (ECF)-type transporters.
J Biol Chem: 2011, 286(7);5471-5
[PubMed:21135102] [WorldCat.org] [DOI] (I p)

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)