Difference between revisions of "MurAB"
| Line 39: | Line 39: | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
| − | + | <br/><br/> | |
| − | |||
| − | |||
| − | |||
| − | |||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| Line 115: | Line 111: | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=murAB_3806086_3807375_-1 murAB] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=murAB_3806086_3807375_-1 murAB] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' constitutive [http://www.ncbi.nlm.nih.gov/sites/entrez/19270101 PubMed] | * '''Regulation:''' constitutive [http://www.ncbi.nlm.nih.gov/sites/entrez/19270101 PubMed] | ||
| Line 142: | Line 138: | ||
=References= | =References= | ||
| + | == Reviews == | ||
| + | <pubmed> 21822642 </pubmed> | ||
| + | == Original publications == | ||
<pubmed>19270101 </pubmed> | <pubmed>19270101 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:52, 9 September 2013
- Description: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
| Gene name | murAB |
| Synonyms | murZ, lssF, rev-4 |
| Essential | no |
| Product | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
| Function | peptidoglycan precursor biosynthesis |
| Gene expression levels in SubtiExpress: murAB | |
| Metabolic function and regulation of this protein in SubtiPathways: Cell wall | |
| MW, pI | 45 kDa, 5.831 |
| Gene length, protein length | 1287 bp, 429 aa |
| Immediate neighbours | glpX, ywjH |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of cell wall components
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU37100
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine (according to Swiss-Prot)
- Protein family: MurA subfamily (according to Swiss-Prot)
- Paralogous protein(s): MurAA
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 3SG1 (from B. anthracis, 50% identity, 81% similarity)
- UniProt: P19670
- KEGG entry: [2]
- E.C. number: 2.5.1.7
Additional information
Expression and regulation
- Regulation: constitutive PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Ankur Gautam, Praveen Rishi, Rupinder Tewari
UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments.
Appl Microbiol Biotechnol: 2011, 92(2);211-25
[PubMed:21822642]
[WorldCat.org]
[DOI]
(I p)
Original publications
Matthieu Jules, Ludovic Le Chat, Stéphane Aymerich, Dominique Le Coq
The Bacillus subtilis ywjI (glpX) gene encodes a class II fructose-1,6-bisphosphatase, functionally equivalent to the class III Fbp enzyme.
J Bacteriol: 2009, 191(9);3168-71
[PubMed:19270101]
[WorldCat.org]
[DOI]
(I p)
