PsdA

• Description: ABC transporter (ATP-binding protein) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin
  
  

Gene name	psdA
Synonyms	yvcR
Essential	no
Product	ABC transporter (ATP-binding protein)
Function	export of toxic peptides
Gene expression levels in SubtiExpress: psdA
Interactions involving this protein in SubtInteract: PsdA
MW, pI	28 kDa, 6.345
Gene length, protein length	777 bp, 259 aa
Immediate neighbours	psdB, psdS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

PsdR regulon

The gene

Basic information

• Locus tag: BSU34700

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • PsdA-PsdB PubMed

• Localization: membrane associated (via PsdB) PubMed

Database entries

• Structure:

• UniProt: O06980

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:
  • psdA-psdB PubMed
  • psdR-psdS-psdA-psdB PubMed

• Expression browser: psdA PubMed

• Sigma factor:
  • psdA: SigA PubMed
  • psdR: SigA PubMed

• Regulation:
  • psdA: induced by nisin, gallidermin (PsdR) PubMed

• Regulatory mechanism:
  • PsdR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517] [WorldCat.org] [DOI] (I e)

Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)