PaiA

• Description: spermine/spermidine-N-acetyltransferase
  
  

Gene name	paiA
Synonyms
Essential	no
Product	spermine/spermidine-N-acetyltransferase
Function	control of intracellular polyamine concentrations
Gene expression levels in SubtiExpress: paiA
Interactions involving this protein in SubtInteract: PaiA
MW, pI	19 kDa, 5.018
Gene length, protein length	516 bp, 172 aa
Immediate neighbours	paiB, sufA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways

The gene

Basic information

• Locus tag: BSU32150

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • AprE-PaiA PubMed

• Localization:

Database entries

• Structure: 1TIQ

• UniProt: P21340

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: paiA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Farhad Forouhar, Alexandre Kuzin, Jayaraman Seetharaman, Insun Lee, Weihong Zhou, Mariam Abashidze, Yang Chen, Wei Yong, Haleema Janjua, Yingyi Fang, Dongyan Wang, Kellie Cunningham, Rong Xiao, Thomas B Acton, Eran Pichersky, Daniel F Klessig, Carl W Porter, Gaetano T Montelione, Liang Tong
Functional insights from structural genomics.
J Struct Funct Genomics: 2007, 8(2-3);37-44
[PubMed:17588214] [WorldCat.org] [DOI] (P p)

Farhad Forouhar, In-Sun Lee, Jelena Vujcic, Slavoljub Vujcic, Jianwei Shen, Sergey M Vorobiev, Rong Xiao, Thomas B Acton, Gaetano T Montelione, Carl W Porter, Liang Tong
Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase.
J Biol Chem: 2005, 280(48);40328-36
[PubMed:16210326] [WorldCat.org] [DOI] (P p)

T Urano, H Ihara, K Umemura, Y Suzuki, M Oike, S Akita, Y Tsukamoto, I Suzuki, A Takada
The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1.
J Biol Chem: 2001, 276(27);24690-6
[PubMed:11325965] [WorldCat.org] [DOI] (P p)