ArgH

• Description: argininosuccinate lyase
  
  

Gene name	argH
Synonyms
Essential	no
Product	argininosuccinate lyase
Function	biosynthesis of arginine
Gene expression levels in SubtiExpress: argH
Metabolic function and regulation of this protein in SubtiPathways: argH
MW, pI	51 kDa, 4.859
Gene length, protein length	1383 bp, 461 aa
Immediate neighbours	ytzD, argG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

AhrC regulon

The gene

Basic information

• Locus tag: BSU29440

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Additional information

• A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine (according to Swiss-Prot)

• Protein family: Argininosuccinate lyase subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1TJ7 (from Escherichia coli, 47% identity, 64% similarity) PubMed

• UniProt: O34858

• KEGG entry: [2]

• E.C. number: 4.3.2.1

Expression and regulation

• Operon: argG-argH PubMed

• Expression browser: argH PubMed

• Sigma factor:

• Regulation:
  • repressed by casamino acids PubMed
  • repressed by arginine (AhrC)

• Regulatory mechanism:
  • AhrC: transcription repression

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: