Difference between revisions of "AdaB"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[DNA repair/ recombination]]}} | + | {{SubtiWiki category|[[DNA repair/ recombination]]}}, |
| + | {{SubtiWiki category|[[prophage 1]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=adaB_204351_204890_1 adaB] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=adaB_204351_204890_1 adaB] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] | + | * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] |
* '''Regulation:''' positive control by [[AdaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] | * '''Regulation:''' positive control by [[AdaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] | ||
Revision as of 11:24, 11 September 2013
- Description: O6-methylguanine-DNA methyltransferase
| Gene name | adaB |
| Synonyms | |
| Essential | no |
| Product | O6-methylguanine-DNA methyltransferase |
| Function | adaptive response to alkylative DNA damage |
| Gene expression levels in SubtiExpress: adaB | |
| MW, pI | 19 kDa, 6.152 |
| Gene length, protein length | 537 bp, 179 aa |
| Immediate neighbours | adaA, ndhF |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
DNA repair/ recombination, prophage 1
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01820
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine (according to Swiss-Prot)
- Protein family: MGMT family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P19220
- KEGG entry: [3]
- E.C. number: 2.1.1.63
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
F Morohoshi, K Hayashi, N Munakata
Bacillus subtilis ada operon encodes two DNA alkyltransferases.
Nucleic Acids Res: 1990, 18(18);5473-80
[PubMed:2120677]
[WorldCat.org]
[DOI]
(P p)
