Btr

• Description: transcription activator (AraC family DNA-binding domain fused to FeuA-like substrate-binding domain), regulation of the feuA-feuB-feuC-ybbA operon
  
  

Gene name	btr
Synonyms	ybbB, yzbC
Essential	no
Product	transcription activator (AraC family)
Function	regulation of iron acquisition
Gene expression levels in SubtiExpress: btr
Metabolic function and regulation of this protein in SubtiPathways: Stress, Metal ion homeostasis
MW, pI	60 kDa, 6.433
Gene length, protein length	1587 bp, 529 aa
Immediate neighbours	feuA, ybbC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

acquisition of iron, iron metabolism, transcription factors and their control

This gene is a member of the following regulons

Fur regulon

The Btr regulon:

• feuA-feuB-feuC-ybbA

The gene

Basic information

• Locus tag: BSU01640

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • binding of a direct repeat in the feuA promoter region and transcription activation of the feuA-feuB-feuC-ybbA operon in the presence of bacillibactin or enterobactin PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): enterobactin, bacillibactin (co-activators) PubMed

• Effectors of protein activity: enterobactin, bacillibactin (co-activators) PubMed

• Interactions:
  • Btr-RNA polymerase (perhaps SigA) PubMed

• Localization:

Database entries

• Structure:

• UniProt: P40408

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: btr PubMed

• Expression browser: btr PubMed

• Sigma factor:

• Regulation:
  • expressed under conditions of iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:
  • the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: