Difference between revisions of "UvrA"
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvzB]]'', ''[[uvrB]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvzB]]'', ''[[uvrB]]'' | ||
|- | |- | ||
| − | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35160 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35160 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35160 | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35160 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35160 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35160 DNA_with_flanks] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:uvrA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:uvrA_context.gif]] | ||
Revision as of 11:23, 14 May 2013
- Description: excinuclease ABC (subunit A)
| Gene name | uvrA |
| Synonyms | |
| Essential | no |
| Product | excinuclease ABC (subunit A) |
| Function | DNA repair after UV damage |
| Gene expression levels in SubtiExpress: uvrA | |
| Interactions involving this protein in SubtInteract: UvrA | |
| MW, pI | 105 kDa, 5.843 |
| Gene length, protein length | 2871 bp, 957 aa |
| Immediate neighbours | yvzB, uvrB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU35160
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: UvrA subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 2R6F (Geobacillus stearothermophilus)
- UniProt: O34863
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Additional information:
Biological materials
- mutant: GP1175 (del uvrAB::ermC) (available in the Stülke lab)
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
James J Truglio, Deborah L Croteau, Bennett Van Houten, Caroline Kisker
Prokaryotic nucleotide excision repair: the UvrABC system.
Chem Rev: 2006, 106(2);233-52
[PubMed:16464004]
[WorldCat.org]
[DOI]
(P p)
Bennett Van Houten, Deborah L Croteau, Matthew J DellaVecchia, Hong Wang, Caroline Kisker
'Close-fitting sleeves': DNA damage recognition by the UvrABC nuclease system.
Mutat Res: 2005, 577(1-2);92-117
[PubMed:15927210]
[WorldCat.org]
[DOI]
(P p)
A Sancar
Mechanisms of DNA excision repair.
Science: 1994, 266(5193);1954-6
[PubMed:7801120]
[WorldCat.org]
[DOI]
(P p)
Original Publications
Bradley T Smith, Alan D Grossman, Graham C Walker
Localization of UvrA and effect of DNA damage on the chromosome of Bacillus subtilis.
J Bacteriol: 2002, 184(2);488-93
[PubMed:11751826]
[WorldCat.org]
[DOI]
(P p)
C M Lovett, K C Cho, T M O'Gara
Purification of an SOS repressor from Bacillus subtilis.
J Bacteriol: 1993, 175(21);6842-9
[PubMed:8226626]
[WorldCat.org]
[DOI]
(P p)
