PsdR

• Description: two-component response regulator, induction of psdA-psdB in response to lipid II-binding lantibiotics, such as nisin and gallidermin
  
  

Gene name	psdR
Synonyms	yvcP
Essential	no
Product	two-component response regulator
Function	resistance against toxic peptides
Gene expression levels in SubtiExpress: psdR
Interactions involving this protein in SubtInteract: PsdR
MW, pI	27 kDa, 4.676
Gene length, protein length	711 bp, 237 aa
Immediate neighbours	psdS, yvzJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics, phosphoproteins

The gene

Basic information

• Locus tag: BSU34720

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: OmpR family of two-component response regulators

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by PsdS on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions:
  • PsdR-PsdS

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O06978

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: psdR-psdS-psdA-psdB PubMed

• Expression browser: psdR PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed