Difference between revisions of "HxlR"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hxlA]]'', ''[[srfAA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hxlA]]'', ''[[srfAA]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03470 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03470 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03470 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03470 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03470 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03470 DNA_with_flanks]
 
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Revision as of 09:27, 14 May 2013

Gene name hxlR
Synonyms yckH
Essential no
Product MarR/DUF24 family transcription activator
Function regulation of the ribulose monophosphate pathway
Gene expression levels in SubtiExpress: hxlR
MW, pI 14 kDa, 6.358
Gene length, protein length 360 bp, 120 aa
Immediate neighbours hxlA, srfAA
Sequences Protein DNA DNA_with_flanks
Genetic context
HxlR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HxlR expression.png


























Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The HxlR regulon:

The gene

Basic information

  • Locus tag: BSU03470

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: formaldehyde stimulates transcription activation by HxlR

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: hxlR (according to DBTBS)
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)

Nobuo Kato, Hiroya Yurimoto, Rudolf K Thauer
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem: 2006, 70(1);10-21
[PubMed:16428816] [WorldCat.org] [DOI] (P p)

H Yasueda, Y Kawahara, S Sugimoto
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
J Bacteriol: 1999, 181(23);7154-60
[PubMed:10572115] [WorldCat.org] [DOI] (P p)