Difference between revisions of "Efp"
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| − | * '''Description:''' elongation factor P <br/><br/> | + | * '''Description:''' elongation factor P, important for the translation of proteins containing three or more consecutive proline residues<br/><br/> |
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|style="background:#ABCDEF;" align="center"| '''Product''' || elongation factor P | |style="background:#ABCDEF;" align="center"| '''Product''' || elongation factor P | ||
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| − | |style="background:#ABCDEF;" align="center"|'''Function''' || translation | + | |style="background:#ABCDEF;" align="center"|'''Function''' || [[translation]] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU24450 efp] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU24450 efp] | ||
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=References= | =References= | ||
| − | <pubmed>15066026, | + | <pubmed>15066026,17981983 23239624 23239623</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 17:34, 29 March 2013
- Description: elongation factor P, important for the translation of proteins containing three or more consecutive proline residues
| Gene name | efp |
| Synonyms | yqhU, yqgF |
| Essential | no |
| Product | elongation factor P |
| Function | translation |
| Gene expression levels in SubtiExpress: efp | |
| MW, pI | 20 kDa, 4.845 |
| Gene length, protein length | 555 bp, 185 aa |
| Immediate neighbours | yqhV, papA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
translation, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU24450
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: transpeptidase family (according to Swiss-Prot) elongation factor P family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot), cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P49778
- KEGG entry: [2]
- E.C. number:
Additional information
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Lili K Doerfel, Ingo Wohlgemuth, Christina Kothe, Frank Peske, Henning Urlaub, Marina V Rodnina
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues.
Science: 2013, 339(6115);85-8
[PubMed:23239624]
[WorldCat.org]
[DOI]
(I p)
Susanne Ude, Jürgen Lassak, Agata L Starosta, Tobias Kraxenberger, Daniel N Wilson, Kirsten Jung
Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches.
Science: 2013, 339(6115);82-5
[PubMed:23239623]
[WorldCat.org]
[DOI]
(I p)
Ulf Gerth, Holger Kock, Ilja Kusters, Stephan Michalik, Robert L Switzer, Michael Hecker
Clp-dependent proteolysis down-regulates central metabolic pathways in glucose-starved Bacillus subtilis.
J Bacteriol: 2008, 190(1);321-31
[PubMed:17981983]
[WorldCat.org]
[DOI]
(I p)
Daniel B Kearns, Frances Chu, Rivka Rudner, Richard Losick
Genes governing swarming in Bacillus subtilis and evidence for a phase variation mechanism controlling surface motility.
Mol Microbiol: 2004, 52(2);357-69
[PubMed:15066026]
[WorldCat.org]
[DOI]
(P p)
