Difference between revisions of "FadN"
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** ''[[fadN]]'': induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}} | ** ''[[fadN]]'': induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}} | ||
** ''[[fadN]]'': subject to carbon catabolite repression ([[CcpA]]-[[PtsH|HPr(Ser-P)]] {{PubMed|12850135,21398533}} | ** ''[[fadN]]'': subject to carbon catabolite repression ([[CcpA]]-[[PtsH|HPr(Ser-P)]] {{PubMed|12850135,21398533}} | ||
| + | ** strongly induced in response to glucose starvation in M9 medium {{PubMed|23033921}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
Revision as of 19:10, 8 October 2012
- Description: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)
| Gene name | fadN |
| Synonyms | yusL |
| Essential | no |
| Product | 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) |
| Function | fatty acid degradation |
| Gene expression levels in SubtiExpress: fadN | |
| Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation | |
| MW, pI | 89 kDa, 6.53 |
| Gene length, protein length | 2445 bp, 815 aa |
| Immediate neighbours | fadA, fadM |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
CcpA regulon, FadR regulon, SdpR regulon
The gene
Basic information
- Locus tag: BSU32840
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH (according to Swiss-Prot)
- Protein family: 3-hydroxyacyl-CoA dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O32178
- KEGG entry: [3]
- E.C. number: 1.1.1.35
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
