Difference between revisions of "ComA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of [[genetic competence]] and [[quorum sensing]] | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of [[genetic competence]] and [[quorum sensing]] | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31680 comA] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/ComA ComA] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/ComA ComA] | ||
| Line 24: | Line 24: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yuxO]]'', ''[[comP]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yuxO]]'', ''[[comP]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU31680 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU31680 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU31680 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:comA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:comA_context.gif]] | ||
Revision as of 13:44, 13 May 2013
- Description: two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)
| Gene name | comA |
| Synonyms | srfB, comAA |
| Essential | no |
| Product | two-component system response regulator |
| Function | regulation of genetic competence and quorum sensing |
| Gene expression levels in SubtiExpress: comA | |
| Interactions involving this protein in SubtInteract: ComA | |
| MW, pI | 23 kDa, 4.759 |
| Gene length, protein length | 642 bp, 214 aa |
| Immediate neighbours | yuxO, comP |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
genetic competence, transcription factors and their control, quorum sensing, phosphoproteins
This gene is a member of the following regulons
The ComA regulon
The gene
Basic information
- Locus tag: BSU31680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ComA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated by ComP on an Asp residue
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P14204
- KEGG entry: [3]
- E.C. number: 4.4.1.19
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Daniel López, Roberto Kolter
Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
FEMS Microbiol Rev: 2010, 34(2);134-49
[PubMed:20030732]
[WorldCat.org]
[DOI]
(I p)
Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575]
[WorldCat.org]
[DOI]
(P p)
Original Publications
