Difference between revisions of "Maf"
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|style="background:#ABCDEF;" align="center"|'''Function''' || cell division control | |style="background:#ABCDEF;" align="center"|'''Function''' || cell division control | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28050 maf] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Maf Maf] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Maf Maf] | ||
| Line 24: | Line 24: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[radC]]'', ''[[spoIIB]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[radC]]'', ''[[spoIIB]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU28050 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU28050 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU28050 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:maf_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:maf_context.gif]] | ||
Revision as of 13:29, 13 May 2013
- Description: cell division inhibitor in competent cells, blocks septation during the escape from competence, required for the stability of ComGA
| Gene name | maf |
| Synonyms | |
| Essential | no |
| Product | cell division inhibitor |
| Function | cell division control |
| Gene expression levels in SubtiExpress: maf | |
| Interactions involving this protein in SubtInteract: Maf | |
| MW, pI | 21 kDa, 5.711 |
| Gene length, protein length | 567 bp, 189 aa |
| Immediate neighbours | radC, spoIIB |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28050
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: maf family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): binds phosphorylated compounds (UTP, IMP, IDP, GDP and others) in in vitro experiments
- Effectors of protein activity:
- Localization:
- near the poles of competent cells PubMed
Database entries
- Structure: 1EX2
- UniProt: Q02169
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original publications
Additional publications: PubMed
Kenneth Briley, Peter Prepiak, Miguel J Dias, Jeanette Hahn, David Dubnau
Maf acts downstream of ComGA to arrest cell division in competent cells of B. subtilis.
Mol Microbiol: 2011, 81(1);23-39
[PubMed:21564336]
[WorldCat.org]
[DOI]
(I p)
Mitsuo Ogura, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.
J Bacteriol: 2002, 184(9);2344-51
[PubMed:11948146]
[WorldCat.org]
[DOI]
(P p)
G Minasov, M Teplova, G C Stewart, E V Koonin, W F Anderson, M Egli
Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proc Natl Acad Sci U S A: 2000, 97(12);6328-33
[PubMed:10841541]
[WorldCat.org]
[DOI]
(P p)
Y X Butler, Y Abhayawardhane, G C Stewart
Amplification of the Bacillus subtilis maf gene results in arrested septum formation.
J Bacteriol: 1993, 175(10);3139-45
[PubMed:8387996]
[WorldCat.org]
[DOI]
(P p)
