Difference between revisions of "YqiD"
| Line 14: | Line 14: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of peptidoglycan and teichoic acid | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of peptidoglycan and teichoic acid | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24280 yqiD] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.021 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.021 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dxs]]'', ''[[yqiC]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dxs]]'', ''[[yqiC]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24280 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24280 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24280 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:yqiD_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yqiD_context.gif]] | ||
Revision as of 13:15, 13 May 2013
- Description: geranyltransferase
| Gene name | yqiD |
| Synonyms | ispA |
| Essential | no |
| Product | geranyltransferase |
| Function | biosynthesis of peptidoglycan and teichoic acid |
| Gene expression levels in SubtiExpress: yqiD | |
| MW, pI | 29 kDa, 5.021 |
| Gene length, protein length | 816 bp, 272 aa |
| Immediate neighbours | dxs, yqiC |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU24280
Phenotypes of a mutant
The mutation of yqiD predisposes cells to grow without a wall PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
Farnasyl pyrophosphate is 15 carbon compound (C15) that is an intermediate in the isoprenoid pathway. In B. subtilis there are two major isoprenoids, the synthesis of both require farnasyl pyrophosphate. The first is heptapreyl pyrophosphate (C35) which acts as a membrane anchor in menaquinone, an electron acceptor in the electron transport chain. The second is undecaprenyl pyrophosphate (C55) which is required to transport both the peptidoglycan precursor, Lipid II, and teichoic acid across the membrane.
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: dimethylallyl pyrophosphate + 2 isopentanyl pyrophosphate -> farnasyl pyrophosphate
- Protein family:
- Paralogous protein(s): HepT
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: None
- Cofactor(s): Magnesium
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P54383
- KEGG entry: [2]
- E.C. number: 2.5.1.10
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
M Leaver, P Domínguez-Cuevas, J M Coxhead, R A Daniel, J Errington
Life without a wall or division machine in Bacillus subtilis.
Nature: 2009, 457(7231);849-53
[PubMed:19212404]
[WorldCat.org]
[DOI]
(I p)
Mattijs K Julsing, Michael Rijpkema, Herman J Woerdenbag, Wim J Quax, Oliver Kayser
Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis.
Appl Microbiol Biotechnol: 2007, 75(6);1377-84
[PubMed:17458547]
[WorldCat.org]
[DOI]
(P p)
Helena B Thomaides, Ella J Davison, Lisa Burston, Hazel Johnson, David R Brown, Alison C Hunt, Jeffery Errington, Lloyd Czaplewski
Essential bacterial functions encoded by gene pairs.
J Bacteriol: 2007, 189(2);591-602
[PubMed:17114254]
[WorldCat.org]
[DOI]
(P p)
David J Hosfield, Yanming Zhang, Douglas R Dougan, Alexei Broun, Leslie W Tari, Ronald V Swanson, John Finn
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis.
J Biol Chem: 2004, 279(10);8526-9
[PubMed:14672944]
[WorldCat.org]
[DOI]
(P p)
