Difference between revisions of "FtsH"
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| − | + | * '''Description:''' ATP-dependent metalloprotease <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || cell division, sporulation initiation | |style="background:#ABCDEF;" align="center"|'''Function''' || cell division, sporulation initiation | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:ftsH_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ftsH_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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** ''[[tilS]]-[[hprT]]-[[ftsH]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed] | ** ''[[tilS]]-[[hprT]]-[[ftsH]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed] | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/7608085 PubMed], [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed] |
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* '''Regulation:''' induced by heat shock (class III) | * '''Regulation:''' induced by heat shock (class III) | ||
Revision as of 10:26, 7 August 2012
- Description: ATP-dependent metalloprotease
| Gene name | ftsH |
| Synonyms | |
| Essential | no |
| Product | ATP-dependent metalloprotease |
| Function | cell division, sporulation initiation |
| Metabolic function and regulation of this protein in SubtiPathways: Phosphorelay, Stress | |
| MW, pI | 70 kDa, 5.841 |
| Gene length, protein length | 1911 bp, 637 aa |
| Immediate neighbours | hprT, coaX |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell division, cell envelope stress proteins (controlled by SigM, V, W, X, Y), heat shock proteins, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00690
Phenotypes of a mutant
strongly reduced sporulation frequency
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: degrades Spo0E and Spo0M, resulting in reduced sporulation frequency in a ftsH mutant PubMed
- Protein family:
- Paralogous protein(s): YjoB
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane PubMed
Database entries
- UniProt: P37476
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: induced by heat shock (class III)
- Regulatory mechanism:
- Additional information: the mRNA is very stable (half-life > 15 min) PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
