HemB

• Description: porphobilinogen synthase
  
  

Gene name	hemB
Synonyms
Essential	no
Product	porphobilinogen synthase
Function	heme biosynthesis
Gene expression levels in SubtiExpress: hemB
MW, pI	36 kDa, 4.98
Gene length, protein length	972 bp, 324 aa
Immediate neighbours	hemL, hemD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, phosphoproteins

This gene is a member of the following regulons

PerR regulon

The gene

Basic information

• Locus tag: BSU28130

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 5-aminolevulinate = porphobilinogen + 2 H₂O (according to Swiss-Prot)

• Protein family: ALADH family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-217 PubMed

• Cofactor(s): zinc

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P30950

• KEGG entry: [3]

• E.C. number: 4.2.1.24

Expression and regulation

• Operon: hemA-hemX-hemC-hemD-hemB-hemL PubMed

• Expression browser: hemB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by hydrogen peroxide (PerR) PubMed

• Regulatory mechanism:
  • PerR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: