PbpX

• Description: penicillin-binding protein X
  
  

Gene name	pbpX
Synonyms
Essential	no
Product	penicillin-binding protein X
Function	endopeptidase
MW, pI	43 kDa, 9.711
Gene length, protein length	1173 bp, 391 aa
Immediate neighbours	recA, rny
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU16950

Phenotypes of a mutant

• increased sensitivity to lysozyme PubMed
• inactivation of pbpX strongly restores beta-lactam resistance in a sigM mutant PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • extracellular (signal peptide) PubMed
  • localizes during sporulation to both asymmetric septa and the prespore Link to a summary

Database entries

• Structure:

• UniProt: O31773

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: pbpX PubMed

• Expression browser: pbpX PubMed

• Sigma factor: SigM PubMed, SigX PubMed

• Regulation:
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed