PenP

• Description: beta-lactamase
  
  

Gene name	penP
Synonyms
Essential	no
Product	beta-lactamase
Function	resistance to beta-lactam antibiotics
MW, pI	33 kDa, 9.208
Gene length, protein length	918 bp, 306 aa
Immediate neighbours	yoaZ, yobA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against toxins/ antibiotics

The gene

Basic information

• Locus tag: BSU18800

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: A beta-lactam + H₂O = a substituted beta-amino acid (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • extracellular (signal peptide) PubMed

Database entries

• Structure: 3KGM (from B. licheniformis, 58% identity, 79% similarity)

• UniProt: P39824

• KEGG entry: [2]

• E.C. number: 3.5.2.6

Expression and regulation

• Operon:

• Expression browser: penP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Birgit Voigt, Haike Antelmann, Dirk Albrecht, Armin Ehrenreich, Karl-Heinz Maurer, Stefan Evers, Gerhard Gottschalk, Jan Maarten van Dijl, Thomas Schweder, Michael Hecker
Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis.
J Mol Microbiol Biotechnol: 2009, 16(1-2);53-68
[PubMed:18957862] [WorldCat.org] [DOI] (I p)