Difference between revisions of "CitA"

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Revision as of 16:39, 18 April 2012

  • Description: minor citrate synthase

Gene name citA
Synonyms citA1
Essential no
Product minor citrate synthase
Function unknown
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 40 kDa, 5.778
Gene length, protein length 1098 bp, 366 aa
Immediate neighbours citR, yhdF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CitA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CitA expression.png




























Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

CitR regulon

The gene

Basic information

  • Locus tag: BSU09440

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Acetyl-CoA + H2O + oxaloacetate = citrate + CoA (according to Swiss-Prot)
  • Protein family: citrate synthase family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism: CitR: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant: GP676 (erm), available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

S Jin, A L Sonenshein
Transcriptional regulation of Bacillus subtilis citrate synthase genes.
J Bacteriol: 1994, 176(15);4680-90
[PubMed:8045899] [WorldCat.org] [DOI] (P p)

S Jin, A L Sonenshein
Identification of two distinct Bacillus subtilis citrate synthase genes.
J Bacteriol: 1994, 176(15);4669-79
[PubMed:8045898] [WorldCat.org] [DOI] (P p)