Difference between revisions of "HtpX"
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | {{SubtiWiki regulon|[[Rok regulon]]}}, | |
| + | {{SubtiWiki regulon|[[YkrK regulon]]}}, | ||
=The gene= | =The gene= | ||
| Line 45: | Line 46: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * increased sensitivity to membrane protein overproduction {{PubMed|22447908}} | ||
| + | * increased sensitivity to dissipation of the membrane potential by the addition of valinomycin {{PubMed|22447908}} | ||
=== Database entries === | === Database entries === | ||
| Line 99: | Line 102: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced by membrane protein overproduction ([[YkrK]]) {{PubMed|22447908}} | ||
| + | ** induced by dissipation of membrane potential (ΔΨ) by addition of a sublethal concentration of valinomycin {{PubMed|22447908}} | ||
| + | ** expression is increased due to mutations in ''[[resE]]'', ''[[resB]]'', ''[[sdhC]]'', and'' [[sdhA]]'' {{PubMed|22447908}} | ||
| + | ** induced by salt stress {{PubMed|22447908}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[YkrK]]: transcription repression {{PubMed|22447908}} | ||
| + | ** [[Rok]]: transcription repression {{PubMed|22447908}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 17:44, 27 March 2012
- Description: similar to E.coli HtpX heat shock protease, stress-responsive membrane protease
| Gene name | ykrL |
| Synonyms | htpX |
| Essential | no |
| Product | membrane protease |
| Function | quality control of membrane proteins |
| MW, pI | 32 kDa, 10.157 |
| Gene length, protein length | 894 bp, 298 aa |
| Immediate neighbours | ykrK, ktrD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
membrane proteins, proteolysis
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13490
Phenotypes of a mutant
- increased sensitivity to membrane protein overproduction PubMed
- increased sensitivity to dissipation of the membrane potential by the addition of valinomycin PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: peptidase M48B family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O31657
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Bogumila C Marciniak, Hein Trip, Fabrizia Fusetti, Oscar P Kuipers
Regulation of ykrL (htpX) by Rok and YkrK, a novel type of regulator in Bacillus subtilis.
J Bacteriol: 2012, 194(11);2837-45
[PubMed:22447908]
[WorldCat.org]
[DOI]
(I p)
