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Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

Contact: General Microbiology, University of Göttingen, send mail

Upcoming events:

• April 16 - 19, 2012: The 5th European Spore Conference will take place in London, UK. contact, conference website
• April 24 - 25, 2012: The BACELL meeting 2012 will be organized by Kevin Devine in Dublin, Ireland. contact, The deadline for registration is approaching!

Past conferences

New: Subtiwiki is now on Facebook - please give it a +1!

Now online: A description of SubtiWiki, SubtiPathways, and SubtInteract in the 2012 Database issue of Nucleic Acids Research

Paper of the month: March 2012

• Buescher et al. and Nicolas et al. from the BaSysBio consortium directed by Philippe Noirot studied the dynamic metabolic and transcriptional responses of B. subtilis to changes of the growth conditions. One of the major issues is the adaptation of the cells upon a nutrient switch from glucose to malate and vice versa. Importantly, the study by Nicholas et al. provides an analysis of gene expression at 104 different conditions as revealed by tiling arrays.
• Relevant SubtiWiki pages: Philippe Noirot, Michael Hecker, Uwe Völker, Philippe Bessières, Uwe Sauer, Stephane Aymerich, Tony Wilkinson, metabolism, transcription, CcpA, Sigma factors, sRNAs, Rho

• A comment on these papers:

• Previous papers of the month

New procedure for account creation:

• Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
  
• Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!

News in SubtiWiki:

• June 2011: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
• April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
• December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
• December 2010: all genes are linked to regulons, and the pages of the regulons provide an overview on all genes that are members of this specific regulon.
• December 2010: all genes/proteins are linked to categories, and the pages of the categories provide an overview on all genes/proteins that are members of this specific category.
• August 2010: several new pathway maps including Utilization of other nitrogen sources, Biotin synthesis, Murein recycling, and Protein secretion were uploaded to SubtiPathways
• March 2010: novel plasmids for the creation of strains expressing proteins with a C-terminal triple FLAG-tag (for simple immunological analysis of the proteins, pGP1087 and pGP1331)

Genes (examples)	Additional pages
spo0A	SubtiPathways
glnA	Lists of genes, proteins and RNAs
rny	Categories
psdA	Regulons
pckA	methods
dnaA	metabolism
rnpA	protein-protein interactions
sigB	genome-wide analyses
ptkA	list of plasmids
mreC	labs working on Bacillus
ccpA	the people behind SubtiWiki
sr1	template

Publications describing SubtiWiki and SubtiPathways:

Lope A Flórez, Sebastian F Roppel, Arne G Schmeisky, Christoph R Lammers, Jörg Stülke
A community-curated consensual annotation that is continuously updated: the Bacillus subtilis centred wiki SubtiWiki.
Database (Oxford): 2009, 2009;bap012
[PubMed:20157485] [WorldCat.org] [DOI] (I p)

Christoph R Lammers, Lope A Flórez, Arne G Schmeisky, Sebastian F Roppel, Ulrike Mäder, Leendert Hamoen, Jörg Stülke
Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 3);849-859
[PubMed:19959575] [WorldCat.org] [DOI] (I p)