Difference between revisions of "PgsA"
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Revision as of 09:22, 13 April 2012
- Description: phosphatidylglycerophosphate synthase
| Gene name | pgsA |
| Synonyms | ymfN |
| Essential | yes PubMed |
| Product | phosphatidylglycerophosphate synthase |
| Function | biosynthesis of phospholipids |
| Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis | |
| MW, pI | 21 kDa, 5.163 |
| Gene length, protein length | 579 bp, 193 aa |
| Immediate neighbours | rodZ, cinA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
biosynthesis of lipids, essential genes, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16920
Phenotypes of a mutant
- some point mutations resulting in reduced PgsA activity lead to daptomycin resistance PubMed
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (according to Swiss-Prot)
- Protein family: CDP-alcohol phosphatidyltransferase class-I family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane at the septum PubMed
Database entries
- Structure:
- UniProt: P46322
- KEGG entry: [2]
- E.C. number: 2.7.8.5
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
