Difference between revisions of "SigM"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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=== Additional information=== | === Additional information=== | ||
| + | * Expression of the [[SigM regulon]] in increased in ''[[ugtP]]'' mutants {{PubMed|22362028}} | ||
=Expression and regulation= | =Expression and regulation= | ||
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<pubmed>18179421,17675383,17434969,</pubmed> | <pubmed>18179421,17675383,17434969,</pubmed> | ||
==Other original publications== | ==Other original publications== | ||
| − | <pubmed>18394148,14993308,12399481,12775685,12207695,18820022,15838020,19047346,14651641,16151214 ,19465659 19745567 10216858 20057163 </pubmed> | + | <pubmed>22362028 18394148,14993308,12399481,12775685,12207695,18820022,15838020,19047346,14651641,16151214 ,19465659 19745567 10216858 20057163 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:05, 4 March 2012
- Description: RNA polymerase ECF-type sigma factor SigM
| Gene name | sigM |
| Synonyms | yhdM |
| Essential | no |
| Product | RNA polymerase ECF-type sigma factor SigM |
| Function | resistance against cell envelope stress, oxidative stress and salt stress |
| Interactions involving this protein in SubtInteract: SigM | |
| MW, pI | 19 kDa, 6.77 |
| Gene length, protein length | 489 bp, 163 aa |
| Immediate neighbours | yhdL, yhdN |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
transcription, sigma factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y)
This gene is a member of the following regulons
The SigM regulon
The gene
Basic information
- Locus tag: BSU09520
Phenotypes of a mutant
- SigM is essential for growth and survival in nutrient broth (NB) containing 1.4 M NaCl PubMed
- sigM mutants form aberrantly shaped cells, which swell and lyse spontaneously during growth in NB medium containing increased levels (0.35-0.7 M) of a wide range of different salts PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: sigma-70 factor family, ECF subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O07582
- KEGG entry: [3]
- E.C. number:
Additional information
- Expression of the SigM regulon in increased in ugtP mutants PubMed
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Additional publications: PubMed
The SigM regulon
Other original publications
