Difference between revisions of "FtsH"

From SubtiWiki
Jump to: navigation, search
m (Reverted edits by 134.76.70.252 (talk) to last revision by Jstuelk)
Line 105: Line 105:
 
** ''[[tilS]]-[[hprT]]-[[ftsH]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed]
 
** ''[[tilS]]-[[hprT]]-[[ftsH]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed]
  
* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/7608085 PubMed], [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed]
+
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsH_76984_78897_1 ftsH] {{PubMed|22383849}}
 +
 
 +
* '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/7608085 PubMed], [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed]
  
 
* '''Regulation:''' induced by heat shock (class III)
 
* '''Regulation:''' induced by heat shock (class III)

Revision as of 11:01, 12 April 2012

  • Description: ATP-dependent metalloprotease

Gene name ftsH
Synonyms
Essential no
Product ATP-dependent metalloprotease
Function cell division, sporulation initiation
Metabolic function and regulation of this protein in SubtiPathways:
Phosphorelay, Stress
MW, pI 70 kDa, 5.841
Gene length, protein length 1911 bp, 637 aa
Immediate neighbours hprT, coaX
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FtsH context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

cell division, cell envelope stress proteins (controlled by SigM, V, W, X, Y), heat shock proteins, membrane proteins

This gene is a member of the following regulons

SigM regulon

The gene

Basic information

  • Locus tag: BSU00690

Phenotypes of a mutant

strongly reduced sporulation frequency

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: degrades Spo0E and Spo0M, resulting in reduced sporulation frequency in a ftsH mutant PubMed
  • Protein family:
  • Paralogous protein(s): YjoB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1LV7 (from E. coli, 64% identity) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by heat shock (class III)
  • Regulatory mechanism:
  • Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References