LmrB

• Description: lincomycin-resistance protein (multidrug resistance pump)
  
  

Gene name	lmrB
Synonyms	yccA
Essential	no
Product	lincomycin-resistance protein
Function	resistance to lincomycin
MW, pI	51 kDa, 9.703
Gene length, protein length	1437 bp, 479 aa
Immediate neighbours	ycbU, lmrA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transporters/ other, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

LmrA regulon

The gene

Basic information

• Locus tag: BSU02670

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: EmrB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O35018

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: lmrA-lmrB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by flavonoids such as quercetin (LmrA)PubMed

• Regulatory mechanism:
  • LmrA: transcription repression PubMed

• Additional information:
  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947