SipS

• Description: signal peptidase I
  
  

Gene name	sipS
Synonyms
Essential	no
Product	signal peptidase I
Function	protein secretion (modulation of the capacity and specificity for protein secretion)
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	20 kDa, 9.718
Gene length, protein length	552 bp, 184 aa
Immediate neighbours	ypuD, ypzC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

protein secretion, membrane proteins

The gene

Basic information

• Locus tag: BSU23310

Expression

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

• Protein family: peptidase S26 family (according to Swiss-Prot)

• Paralogous protein(s): SipT, SipU, SipV

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: membrane

Database entries

• Structure:

• UniProt: P28628

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sipS PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands