Difference between revisions of "NiaP"
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' nicotinate transporters <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || nicotinate transporters |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || uptake of niacin |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 43 kDa, 9.502 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 43 kDa, 9.502 | ||
| Line 33: | Line 33: | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[transporters/ other]]}}, | {{SubtiWiki category|[[transporters/ other]]}}, | ||
| + | {{SubtiWiki category|[[biosynthesis of cofactors]]}}, | ||
{{SubtiWiki category|[[membrane proteins]]}} | {{SubtiWiki category|[[membrane proteins]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | {{SubtiWiki regulon|[[NadR regulon]]}} | |
=The gene= | =The gene= | ||
| Line 53: | Line 54: | ||
=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| Line 63: | Line 62: | ||
* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | * '''Protein family:''' | + | * '''Protein family:''' MFS transporter {{PubMed|18276644}} |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
| Line 71: | Line 70: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''Domains:''' 10 membrane-spanning domains {{PubMed|18276644}} |
* '''Modification:''' | * '''Modification:''' | ||
| Line 81: | Line 80: | ||
* '''Interactions:''' | * '''Interactions:''' | ||
| − | * '''Localization:''' cell | + | * '''Localization:''' cell membrane [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] |
=== Database entries === | === Database entries === | ||
| Line 102: | Line 101: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** repressed in the presence of nicotinic acid ([[NadR]]) {{PubMed|18276644}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[NadR]]: transcription repression {{PubMed|18276644}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 126: | Line 127: | ||
=References= | =References= | ||
| − | + | ==Reviews== | |
| − | <pubmed>18763711, </pubmed> | + | <pubmed> 21953179 </pubmed> |
| + | ==Original publications== | ||
| + | <pubmed>18763711, 18276644 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:26, 30 September 2011
- Description: nicotinate transporters
| Gene name | yceI |
| Synonyms | |
| Essential | no |
| Product | nicotinate transporters |
| Function | uptake of niacin |
| MW, pI | 43 kDa, 9.502 |
| Gene length, protein length | 1200 bp, 400 aa |
| Immediate neighbours | yceH, yceJ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
transporters/ other, biosynthesis of cofactors, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU02950
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: MFS transporter PubMed
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: 10 membrane-spanning domains PubMed
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane PubMed
Database entries
- Structure:
- UniProt: O34691
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Linda Jeanguenin, Aurora Lara-Núñez, Dmitry A Rodionov, Andrei L Osterman, Nataliya Y Komarova, Doris Rentsch, Jesse F Gregory, Andrew D Hanson
Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals.
Funct Integr Genomics: 2012, 12(1);25-34
[PubMed:21953179]
[WorldCat.org]
[DOI]
(I p)
Original publications
Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711]
[WorldCat.org]
[DOI]
(I p)
Dmitry A Rodionov, Xiaoqing Li, Irina A Rodionova, Chen Yang, Leonardo Sorci, Etienne Dervyn, Dariusz Martynowski, Hong Zhang, Mikhail S Gelfand, Andrei L Osterman
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Nucleic Acids Res: 2008, 36(6);2032-46
[PubMed:18276644]
[WorldCat.org]
[DOI]
(I p)
