Difference between revisions of "Btr"

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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:''' transcription activation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon in the presence of bacillibactin or enterobactin [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]
+
* '''Catalyzed reaction/ biological activity:'''
 +
** binding of a direct repeat in the ''[[feuA]]'' promoter region and transcription activation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon in the presence of bacillibactin or enterobactin {{PubMed|17725565,22210890}}
  
 
* '''Protein family:'''
 
* '''Protein family:'''
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* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):''' enterobactin, bacillibactin (co-activators) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]
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* '''Cofactor(s):''' enterobactin, bacillibactin (co-activators) {{PubMed|17725565}}
  
* '''Effectors of protein activity:''' enterobactin, bacillibactin (co-activators) [http://www.ncbi.nlm.nih.gov/sites/entrez/17725565 PubMed]
+
* '''Effectors of protein activity:''' enterobactin, bacillibactin (co-activators) {{PubMed|17725565}}
  
 
* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
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** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
 
** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
  
* '''Additional information:'''  the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
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* '''Additional information:'''   
 +
** the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
  
 
=Biological materials =
 
=Biological materials =
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=References=
 
=References=
  
<pubmed>12884008,17725565,,12354229, </pubmed>
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<pubmed>12884008,17725565, 22210890,12354229, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 17:25, 4 January 2012

  • Description: transcription activator (AraC family DNA-binding domain fused to FeuA-like substrate-binding domain), regulation of the feuA-feuB-feuC-ybbA operon

Gene name btr
Synonyms ybbB, yzbC
Essential no
Product transcription activator (AraC family)
Function regulation of iron acquisition
Metabolic function and regulation of this protein in SubtiPathways:
Stress, Metal ion homeostasis
MW, pI 60 kDa, 6.433
Gene length, protein length 1587 bp, 529 aa
Immediate neighbours feuA, ybbC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YbbB context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

acquisition of iron, iron metabolism, transcription factors and their control

This gene is a member of the following regulons

Fur regulon

The Btr regulon:

The gene

Basic information

  • Locus tag: BSU01640

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • binding of a direct repeat in the feuA promoter region and transcription activation of the feuA-feuB-feuC-ybbA operon in the presence of bacillibactin or enterobactin PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): enterobactin, bacillibactin (co-activators) PubMed
  • Effectors of protein activity: enterobactin, bacillibactin (co-activators) PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under conditions of iron starvation (Fur) PubMed
  • Regulatory mechanism:
  • Additional information:
    • the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References